My sick days are all rolled into my PTO, because I work from home (even pre-covid) :whistle:

Haven't watched yet, just woke up, but do they account for the fact that Pfizer/Biontech was used to vaccinate the entire population of Israel? I know they got quite a bit of information from that.

No, all the data used for efficacy rates is from their respective phase 3 trials

Yeah I know they learned from Israel that cases actually went up above normal for a few days after first dose, then stayed at around 0% immunity for about 2 weeks, then it quickly ramped up to 90% by 3 weeks. Before Israel, they didn't know it was that high after the first dose.

We're learning new stuff about these vaccines every day it seems. Hopefully nothing bad :fuckthatshit:

VANCOUVER (NEWS 1130) – B.C.’s top doctor is expressing concern over younger people ending up in the hospital because of COVID-19 as the province continues immunizing people against the virus.

We have seen several young people in their 30s, and 40s who, unfortunately, tragically, been severely affected by COVID,” Henry said, adding data on the age of patients hospitalized is still in the works. “[COVID_19] is still, of course, riskier the older you are, but as we are protecting more and more older people, we are seeing risk in younger people.”

B.C. reported 1,437 new infections, 16 deaths over three-day period on Monday


Is it safe to say that BC has hit the third wave of this pandemic?

The younger age range of people in their 30s ending up in hospital with Covid is a bigger concern now.


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I wouldn't call it the 3rd wave if the second didn't even subside. Going to be a big eye opener when people see their friends in hospital for this. It's a vaccine race to make sure this isn't a disaster, and we are losing the race.

vaccines to ramp up for surrey

https://globalnews.ca/news/7712936/b...ions-teachers/

Lots of peolpe here in Whistler are receiving the vaccination this week. I had no idea that I'd be one of those people when I woke up this morning but I got the call midday with just a few hours notice to head over. They gave me the Covishield vaccine. I havent felt any side effects so far.

Well, its controversies like these that don't instill public's faith and confidence in AstraZeneca. Maybe you have a higher personal risk tolerance (or faith in private pharma corps?) but that shouldn't lead you to look down on people who are being skeptical at all these confusing headlines.

----------------------

Tuesday, March 23, 2021

NIAID Statement on AstraZeneca Vaccine

https://www.nih.gov/news-events/news...zeneca-vaccine

Late Monday, the Data and Safety Monitoring Board (DSMB) notified NIAID, BARDA, and AstraZeneca that it was concerned by information released by AstraZeneca on initial data from its COVID-19 vaccine clinical trial. The DSMB expressed concern that AstraZeneca may have included outdated information from that trial, which may have provided an incomplete view of the efficacy data. We urge the company to work with the DSMB to review the efficacy data and ensure the most accurate, up-to-date efficacy data be made public as quickly as possible.

----------------------

Then you have scientists basically saying that the US government has stopped just short of accusing AstraZeneca of manipulating its trial data.

https://twitter.com/BallouxFrancois/...ete-trial-data

----------------------

Criticisms of AstraZeneca studies stem back to the first data released in the UK, which purported to show that the jab was 70% effective. However, the trial data didn't account for a manufacturing mistake, and also didn't include enough participants over the age of 65 to deduce efficacy among older patients. European governments like Germany and France responded by initially limiting the jab to patients under the age of 65. US authorities suspended the US trial for 6 weeks last fall for mysterious reasons that were never fully explained. Following the latest release, Astrazeneca head of research and development Mene Pangalos called the data "much cleaner" than prior releases, expressing hope it "puts to bed any doubts."

AstraZeneca said yesterday's trial conclusions were based on an "interim analysis" with all data received by the cutoff date of Feb. 17. Then, it promised to "immediately engage with the independent data safety monitoring board to share our primary analysis with the most up to date efficacy data." Results of this primary analysis will be available within 2 days.

https://www.astrazeneca.com/media-ce...rial-data.html

The numbers published yesterday were based on a pre-specified interim analysis with a data cut-off of 17 February.

We have reviewed the preliminary assessment of the primary analysis and the results were consistent with the interim analysis. We are now completing the validation of the statistical analysis.

We will immediately engage with the independent data safety monitoring board (DSMB) to share our primary analysis with the most up to date efficacy data.

We intend to issue results of the primary analysis within 48 hours.

monkaS

Edit: This story is inaccurate, as this batch comes from China, not Germany. (not true, see below)

Just when I was telling my wife that the pharmaceuticals made in China should be the same quality as anywhere else, as long as they adhere to the standards made by Pfizer and BioNTech. Like literally an hour before this happened. FailFish

Edit 2: It's possible that the batch is from Pfizer, and Fosun simply handles the administrative portion with HK and Macau at this time. I've yet to see a source either way (my syringe was preloaded, so I couldn't look at the vial for a label) (somewhat true, see below)

Edit 3: I finally got some concrete information. BioNTech developed the vaccine, and partners with Pfizer to manufacture and release it around the world, except China. They partner with Fosun for packaging, shipping, marketing, but not manufacturing. They still manufacture it themselves in Germany, ship it to China, then it goes from there. Fosun is developing a plant to make it themselves eventually, but there's no timeline for it, and it is likely many years from happening.

Still not sure what the defect is. It's possible its cold storage wasn't maintained, or some vials leaked, or anything really. Have to wait and see when (if) they give full details.

Hong Kong is an absolutely shxt show with the government COVID efforts. If I were in living in Hong Kong, I wouldn't trust the BioNTech vaccine there either.

(And then it goes without saying that I woudln't trust the Sinovac vaccine under any circumstances -- and there is plenty of emprical data around the world to support that too.)

The issue with Sinovac isn't that it's from China, it's that it hasn't been tested thoroughly, and the data that is there seems unreliable, and what reliable data there is doesn't show it to be very effective. Also they seem to be using HKers as guinea pigs (giving it to >60 even though they don't do that anywhere else) and they seem to want to promote it heavily (yesterday they took a doctor off the program who was telling his patients that the BioNTech one is more effective) and then Carrie Lam complained about "fake news" and "rumors".

If Sinovac was the only choice, I wouldn't have gotten a vaccine yet. I'd buy another one myself privately if I had to.

Immediately people here are saying this has been fabricated in order to switch everyone to Sinovac.

well there goes my shot today..
har har har har har

New variant is basically starting the pandemic all over again. It's more 40-60% contagious, and 64% more deadly than OG covid.


https://pbs.twimg.com/media/EtcL722WQAAESEc.jpg

BioNTech and Moderna vaccines are effective against this variant (but barely counter the B1351 "South Africa" variant)

https://pbs.twimg.com/media/EweDwqDWgAQAkuS.jpg

I’m burned out on covid-19. I know a lot of people feel the same =_=

Hard not to when doctors are literally saying the BionTech/Pfizer shot is preferred. Like the dude that got suspended the other day...

something like 50 vials out of 550000 were broken... it isn't very difficult to grab the next one is it?

normally, i ignore the conspiracies etc.. but this one just seems odd, how is it that this factory has delivered probably millions of this shot to other countries, yet Hong Kong/Macau is the only one that has an "issue"

You have to err on the side of caution when this happens.. This would be the case in any country. Yeah 50 vials out of the 30K (150K doses so far, 5 doses per vial) that have been used is a small fraction, it's good to halt for a bit and figure out if the whole batch is tainted. If everything is fine, they can go back and use this batch. If anything this shows how good their testing procedure is.

The dude getting suspended is pretty shitty. But doctors can only give out the sinovac anyway, biontech is only done at the community centres, so if he's telling his patients not to get it, he might as well not be in the program. It sucks that they tell you to "ask your doctor for more information" but when the doctor gives you the facts, he gets banned from the program. The govt is so fucking clueless to do this, but it's china now so what do you expect?

i can tell you for a fact that dropping/breaking 50 vials is absolutely ludicrous. you'd have to be a butter fingered goon to be this careless. in the ~8 years i've been at my current hospital, I've dropped and broken 2 or 3 vials. total.

any more details as to how/why this guy broke so many? honestly, no matter what the circumstances there isn't much excuse.

Buddy of mine got the covishield shot yesterday. Was up all night puking with a fever and said a “state of confusion” a little better today but still pretty rough

That happens to me after every wedding I go to.

They're not dropping them, the vials are coming to them with loose caps (the aluminum caps, not the plastic part that protects the rubber seal) and leaks. That's why they're discontinuing to find out why. It's possibly due to the temperature change, or were screwed up right from the manufacturer, or something else

Another 700 plus today:pokerface:. Surrey is still winning

I can't say who trusts what or which one is better. Tons of debate on china vaccine versus mRNA ... just diff methods.

I can say for a city like HK, they are allowing 18 yr olds to get the vaccine (ot at lesat be in line0... that's hella fast / efficient (news as per March 24 Singtao). Going to fact check the shit out of that but if that's the case.. dang.. YVR is slow as fuck.

Not complaining, distribution and obtaining is diff from Canada / BC / HK.

Everyone reacts differently. Of the 30+ people of front line friends i have 80% had headaches and arm hurts on the 1st dose, 2nd one is worse and you might be out of work for a day or two so that's interesting to know.

Drove my dad to get his vaccination shot today at Central Park. Whole thing took around 20 minutes