[Soundy]

Drivers for NEW hardware shouldn't be a problem... drivers for older hardware, though, especially abandoned, cheap, or off-brand hardware, is another matter. Major manufacturers have been writing 64-bit drivers since XP-64 was in beta, and even most minor ones got into the fray when Vista was announced.

Same deal with software, some older 32-bit stuff especially may have issues... mostly non-mainstream stuff, especially since more mainstream stuff will have updates or patches available, but there is a fair bit of older stuff out there that will have problems.