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What kind of PSU do you have?
I assume you tried unplugging the new harddrive and seeing if it turns on?
Also you mentioned you "loosened up the heatsink". I'm not sure entirely what you mean but if it isn't seated properly it won't be cooling the CPU and that will cause your problems. Before replacing anything get some thermal compound if you don't have any, take the HSF off and clean both sides with some q-tips and microfibre cloth. Thoroughly clean the HSF while you're at it. Apply the thermal compound (google the best way to do it if you don't know how - I like the bean/rice blob method) and re-attach the HSF. If you're problems persist it's most likely your PSU which will require more troubleshooting to determine.
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