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I had an HD 4870 on an Antec Earthwatts EA-500 PSU and it didn't go so well. Random lockups, occasional BSOD ... Upgraded to a better PSU and never had a problem ...
The 5850 isn't as power hungry as the 4870 was, but I'd still go w/ at least a 500W PSU based on past experience plus the price difference isn't huge. Going w/ a larger PSU will afford you more upgrade opportunities.
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