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So I'll chime in being a avid user of avast. I have no clue what spybot is, yet I know if your running avast at High Protection instead of normal, it decreases your speed substantially. I've customized my avast to not look through programs that I never use and to use a Light scan on specific sections and programs because I know when I get a virus or not. I good thing to use aswell to speed up your computer could be a registry cleaner.
Same thing Dragon-88 is mentioning, with "msconfig" it's specifically for start-up, you could try a program called "HiJackThis", I wouldn't suggest it to someone who doesn't know much about computers but it might help. If you download that program and run a scan, post a PrintScreen image and maybe I can help abit more.
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