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I have driven from Van to LA about a dozen times. Take about 20-24 hours total depending on road conditions if you take the I5. The coast (101) takes a lot longer.
When are you planning on going? Now? Spring? Summer?
If you are leaving in the winter, CHECK THE CONDITIONS!! Areas around Grants Pass can be pretty brutal and sometimes you are required to have chains. During the summer is it pretty easy, but bring coolant as too_slow suggested. Sometimes after through the hot desert before up the mountains before the decent into LA, you engine can go a little haywire (you will see a lot of cars on the side of the road with coolant issues).
Are you planning on driving straight or stopping over night along the way? I can give you some ideas of where to stop and how to break it up. I know that drive very well...
If you are driving alone, I'm not sure I would suggest driving straight through...
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