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I did the drive a few years ago around mid April. Around Mt Shasta/ Norcal, there was still snow and -2 ish. So be extra cautious in that area. The drive is very nice until you past Mt Shasta, then it's a straight line for a good 5-6 hours.
San Fran to LA wasn't so bad. Got to LA in about 5 hours from there.
CHP are everywhere though, so just remember to drive within a convoy.
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