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Don't use poison, because:
A. It's inhumane.
B. The rat will most likely die in a wall and rot.
Rat poison acts on the kidneys, shutting them down and preventing the body from being able to absorb water. As a result the rat will desperately try to find every bit of water it can since it's essentially dying of thirst, that water might be outside or it might be a pipe sweating in your wall.
If you need to kill them, use snap traps, or buy a cat, or a snake......
What you really need to do is address where they're accessing the home, as Gridlock suggested. Check all around the outside of your home and seal off any potential entrance points, the roof line is a very common place for them to come in.
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