I'm going to try and sway you back. Wheels are huge IMO. The RS10's get the job done, but they are heavy and on the flexier side. You'll have a stiffer and more responsive/efficient ride with lighter wheels, and knocking off 400g is ~25%, and that is rotational mass. The Reynolds are pretty darn good bang for the buck. Combine that with improved and ligher tires and tubes, and you are golden. The improvement gained from wheels > changing from mid-end to top-line drivetrain/brakes IMO. Just think of the difference you found from going 105-Red, and multiply that 2-3x.
And factor in you can probably sell your RS-10's for about $150, you're really only paying $200 to get that upgrade