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for the longest time the israeli mossad carried .22lr pistols, specifically the beretta 70/71's
with the right shot placement .22lr is just as lethal as any other calibre for a kill shot imo (something like cci mini mags would be a good choice).
for home defence though i'd be grabbing a pistol grip shotgun loaded with low recoil 00 buckshot. in a pistol i'd be looking for something in .40s&w or .357. m&p, glock, sig, etc.
i have a friend who worked in the field quite a bit for transport canada and his shotgun was loaded 00, slug, 00, slug, 00.
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