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If it is a night flight you are much better setup already. As stated above, ear plugs, eye mask and a neck pillow will be your friends. Window seat, or sitting beside someone with a bigger bladder is also very important.
The sleep aids in the pharmacy I find actually work pretty well. They won't knock you out if your wide awake, but taking them when relaxed, especially in the evening you should be able to get to sleep. You will feel a bit of a sleep hangover from what i've experienced in the past for about 12 hours from the time you take the drug. Most of them are an antihistamine.
The day of the trip, do a lot of exercise and tire yourself right out. Keep the liquid intake fairly low approaching flight time (Don't come dehydrated), and make sure to get one last pee in before you shut your eyes.
If you can actually get 8 hours i'll be thoroughly impressed. I've only ever done that in a pod. Good luck! If it's a daytime flight, without actual prescribed medicine, I'd say your right out of luck unless you really have no sleep schedule at all.
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