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The game will use between 6.5GB and 10GB of system RAM, depending on what graphics card you have, and the game settings. 16GB of system RAM is recommended, although 8GB works if you close almost everything else while playing. If you have a bunch of things open in the background while playing, even more than 16GB of RAM could be helpful.
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I have two 1080s in SLI and I find for gameplay sake running low is best for me.
This site has a pretty good breakdown on what each setting does and the effect it has on performance.